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Backbone structure metallic moieties

Analysis of the solution stmcture of a protein can be carried out by using redox-active metal centers (25). For example, [Cu(phen)2] was exploited in the structural analysis of Escherichia coli lactose permease, a paradigm for membrane transport proteins (73). By the reaction of Y with a functional lactose permease mutant, phen was covalently linked to a single cysteine residue situated within one of the 12 membrane-spanning a-helices of the protein. After Cu(n) ion was bound to the phen moiety of the modified protein and ascorbate was added in the presence of O2, efficient, localized scission (up to 30%) of the protein backbone was observed in adjacent helices, providing information on the structure of the protein. [Pg.90]

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Backbone structures

Metallic moieties

Structural backbone

Structural moiety

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