Exotoxin, from Bacillus thuringiensis

M. Prystas, L. Kalvoda, and F. Sorm, Alternative synthesis of exotoxin from Bacillus thuringiensis, Collect. Czech. Chem. Commun., 41 (1976) 1426-1447. 

The unusual 1,6-anhydro disaccharide 283, having an ether instead of a glycosidic linkage, was synthesized as an intermediate in the preparation of the exotoxin from Bacillus thuringiensis.442-5320,534,542 758-759... 

Three exotoxins were isolated from the supernatant liquid of Bacillus thuringiensis cultures. Among these, -exotoxin has been investigated most extensively. Its structure has not yet been established, but it is probably a nucleotide containing adenosine monophosphate (Heimpel, 1967 McConnel and Richards, 1959 De Barjac and Dedonder, 1965 Benz, 1966 Sebesta and Horska, 1968 Rogoff, 1966 Farkas et al 1969). 

The insecticidal exotoxin (346) isolated from Bacillus thuringiensis has been identified as a 5 -adenosyl derivative of 5-O-a-D-glucopyranosylallaric acid 3-phosphate. "... 

A series of papers from Sorm s group has given details of their approaches to the synthesis of the exotoxin (391) produced by Bacillus thuringiensis. The first paper describes the synthesis of the protected disaccharide moiety (394),... 

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