Azoreductases biodegradation

Biodegradation of Azo Dyes Under Anaerobic Condition Role of Azoreductase... 

The yeast-mediated enzymatic biodegradation of azo dyes can be accomplished either by reductive reactions or by oxidative reactions. In general, reductive reactions led to cleavage of azo dyes into aromatic amines, which are further mineralized by yeasts. Enzymes putatively involved in this process are NADH-dependent reductases [24] and an azoreductase [16], which is dependent on the extracellular activity of a component of the plasma membrane redox system, identified as a ferric reductase [19]. Recently, significant increase in the activities of NADH-dependent reductase and azoreductase was observed in the cells of Trichosporon beigelii obtained at the end of the decolorization process [25]. 

The most widely used intestinal microbial strains used to test colon targeting and enzymatic biodegradation of the carrier, respectively, are microorganisms with azoreductases and different types of glycosidases. 

Hansen LG, Kapoor IP, Metcalf RL (1972) Biochemistry of selective toxicity and biodegradability comparative (9-dealkylation by aquatic organisms. Comp Gen Pharmac 3 339-344 Hanzel ME, Carlson GP (1974) Azoreductase activity in the hard clam, Mercenaria mercenaria (L.). J Exp Mar Biol Ecol 14 225-229... 

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