Didanosine Azithromycin

Azithromycin, fluoroquinolones, ketoconazole, isoniazid, penicillin, rifampin, and tetracycline ° Didanosine, indinavir, stavudine, and zidovudine ° Aledronate, risedronate, and levodopa... 

Drugs that may affect nelfinavir include anticonvulsants, azithromycin, azole antifungals, efavirenz, delavirdine, HMG-CoA reductase inhibitors, indinavir, interleukins, nevirapine, rifabutin, rifampin, ritonavir, saquinavir, St. John s wort. Drugs that may be affected by nelfinavir include amiodarone, antiarrhythmics (amiodarone, quinidine), azithromycin, benzodiazepines, efavirenz, ergot alkaloids, delavirdine, didanosine, fentanyl, indinavir, lamivudine methadone, nonsedating antihistamines, oral contraceptives, phenytoin, pimozide, quinidine, rifabutin, saquinavir, sildenafil, sirolimus, tacrolimus, zidovudine. 

Clarithromycin causes some reduction in the bioavailability of zidovudine, but this is minimised if the two drugs are given at least 2 hours apart. Clarithromycin does not appear to interact with didanosine, stavudine or zalcitabine, and azithromycin does not interact with didanosine or zidovudine. 

When azithromycin 1.2 g daily for 14 days was given to 12 HIV-positive subjects with didanosine 200 mg twice daily there was no significant change in the pharmacokinetics of either drug. ... 

The authors of the report on didanosine conclude that clarithromycin may safely be given with didanosine, and it also seems likely that didanosine or zidovudine and azithromycin stavudine and clarithromycin and zalcitabine and clarithromycin can be used safely together. 

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