Aziridines from 2-haloamines

The synthesis of aziridines from /i-haloamines (Gabriel synthesis) is very general and has been used extensively. 

Quantitative aziridination from aminobrominated derivatives of olefins under solvent-free grinding was developed (12ChinJC391). 1,2-Vicinal haloamine, urea, and anhydrous K2CO3 were admixed in an agate mortar. Then, the solid mixture was ground at room temperature in air. The progress was monitored by TTC for each 5 min interval. 

Gabriel ethylenimine method. Formation of ethylenimines (aziridines) by elimination of hydrogen halides from aliphatic vicinal haloamines with alkali. The method can be extended to the preparation of five- and six-membered ring amines. 

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