8-azido-cAMP

Aryl azides are rather bulky groups to append to a ligand, particularly to a small organic molecule, but it has proved possible in many cases to build the reactive group into the structure of a molecule, for instance 8-azido-cAMP and 4-azido-phenylalanine (Fig. 3.2). 

Azido-cAMP Erythrocyte membranes Two proteins labeled cAMP protects More efficient than the diazomalonyl derivative 52... 

Azido-cAMP Protein kinase from bovine brain Labels the component that can also be phosphorylated by ATP cAMP protects 53... 

Cyclic Nucleotides.—New analogues of cAMP and cGMP that have been reported include 2-fluoroadenosine 3, 5 -monophosphate, 9-/ -D-xylofuranosylguanine 3, 5 -monophosphate, 8-carbamoyl- and 8-carboxy-adenosine 3, 5 -monophosphates (prepared from 8-bromo-cAMP, using standard transformations), and a series of 2-substituted-l,A -ethenoadenosine 3, 5 -monophosphates, prepared by ring reclosure of (30), which is the product of alkaline hydrolysis of 1, N -etheno-cAMP. The last-named have useful fluorescent properties, like the parent compound. So, also, have 8-azido-l,N -ethenoadenosine 3, 5 -monophosphate (also prepared... 

The phosphoramidate analogues (619) of cAMP and improved syntheses of 5 -azido-5 -deoxythymidine and 5 -azido-2, 5 -dideoxyadenosine and their S -phosphates " have been reported. 

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