Azides nucleotide modification

For RNA, artificial self-cleaving hammerhead ribozymes with a triazole linkage at the active site are reported [26]. Interestingly, triazole backbone modifications in RNA by CuAAC and SPAAC chemical hgation of 3 -azide and 5 -cyclooctyne oligonucleotides can further be reverse transcribed into DNA while one nucleotide is omitted at the linkage [95]. 

Modifications of Nucleosides, Nucleotides, and Nucleic Acids using Huisgen s [3+2] Azide-Alkyne Cycloaddition ... 

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