Azide complex hydrides

Reduction by complex hydrides Azide ions and nitrite ions Nucleophilic Attack at Hydrogen. 6.1 Metalation at a ring carbon atom... 

Reduction of the polymer-linked 1,2-trans azide 226 with complex hydrides was not successful. Under the conditions of the Staudinger reaction (see Section... 

The importance of reactions with complex, metal hydrides in carbohydrate chemistry is well documented by a vast number of publications that deal mainly with reduction of carbonyl groups, N- and O-acyl functions, lactones, azides, and epoxides, as well as with reactions of sulfonic esters. With rare exceptions, lithium aluminum hydride and lithium, sodium, or potassium borohydride are the... 

Germanes hydride, 2 76 reactivity of, 2 87 Germanium anionic cluster, 24 227 azides, preparation, 9 138 properties, 9 135-136, 139, 141 binary carbide not reported, 11 211 carbides, preparation of, 11 163 chalcogenide halides, 23 390 chlorides, mass spectra of, 18 248, 249 complexes, xenon fluoride reactions, 46 85 compounds, see also Organogermanium compounds... 

The seemingly complex imidazolone (78-3) is in fact obtained in a single step by reaction of the amino-ester (78-1) with the iminoether (78-2) derived from capro-nitrile. The relatively acidic proton on the heterocyclic ring is next removed by reaction with sodium hydride. This anion is then alkylated with the same biphenyl-methyl bromide (77-2) that was used to prepare losartan to afford (78-4). The nitrile group is in this case converted to the tetrazole by means of tributyltin azide, a reagent that involves milder conditions than the traditional acidic medium used to generate hydrazoic acid. Thus, treatment of (78-4) with the tin reagent affords irbesartan (75-5) [82]. 

Nucleophilic attack on ( -alkene)Fp+ cations may be effected by heteroatom nucleophiles including amines, azide ion, cyanate ion (through N), alcohols, and thiols (Scheme 39). Carbon-based nucleophiles, such as the anions of active methylene compounds (malonic esters, /3-keto esters, cyanoac-etate), enamines, cyanide, cuprates, Grignard reagents, and ( l -allyl)Fe(Cp)(CO)2 complexes react similarly. In addition, several hydride sources, most notably NaBHsCN, deliver hydride ion to Fp(jj -alkene)+ complexes. Subjecting complexes of type (79) to Nal or NaBr in acetone, however, does not give nncleophilic attack, but instead results rehably in the displacement of the alkene from the iron residue. Cyclohexanone enolates or silyl enol ethers also may be added, and the iron alkyl complexes thus produced can give Robinson annulation-type products (Scheme 40). Vinyl ether-cationic Fp complexes as the electrophiles are nseful as vinyl cation equivalents. ... 

S.4.2. by Reaction of an Organotin Azide with a Transition- or inner Transition-Metal-Hydride Complex. 

---