Azathioprine Sodium

Brand Name(s) Azasan, Azathioprine Sodium, Imuran... 

Azanin - Azathioprine Azapen Methicillin sodium Azapress - Azathioprine Azene Chlorazepate dipotassium Azepamid -Medazepam Azide Chlorothiazide Aziin - Aziocillin... 

Azathioprine Azathioprine, 6-[(l-methyl-4-nitroimidazol-5-yl)thio]purine (31.2.1), is synthesized by heteroarylation of the sulfhydrile group of 6-mercaptopurine (30.1.2.9) with 5-chloro-l-methyl-4-nitroimidazol in the presence of sodium acetate as a weak base [13]. 

Mycophenolate mofetil is used together with cyclosporine and corticosteroids for the prophylaxis of acute organ rejection in patients undergoing allogeneic renal, or hepatic transplants. Compared with azathioprine it is more lymphocyte-specific and is associated with less bone marrow suppression, fewer opportunistic infections and lower incidence of acute rejection. More recently, the salt mycophenolate sodium has also been introduced. Mycophenolate mofetil is rapidly hydrolyzed to mycopheno-lic acid, its active metabolite. Mycophenolic acid is a reversible noncompetitive inhibitor of inosine monophosphate dehydrogenase, an important enzyme for the de novo synthesis of purines. As lymphocytes have little or no salvage pathway for purine... 

Electrolyte imbalance, and diseases that lead to electrolyte imbalance, such as adrenal cortical insufficiency, alter neuromuscular blockade. Depending on the nature of the imbalance, either enhancement or inhibition may be expected. Magnesium sulfate, used in the management of toxemia of pregnancy, enhances the skeletal-muscle-relaxing effects of pancuronium. Antibiotics such as aminoglycosides, tetracyclines, clindamycin, lincomycin, colistin, and sodium colistimethate augment the pancuronium-induced neuromuscular blockade. Anesthetics such as halothane, enflurane, and isoflurane enhance the action of pancuronium, whereas azathioprine will cause a reversal of neuromuscular blockade. 

Internal standard 9-methylazathioprine (Add 400 mg anhydrous potassium carbonate and 200 pL methyl iodide to a solution of 220 mg azathioprine in 7 mL DMF at 0-5°, stir under nitrogen for 24 h, add 14 mL water, neutralize with 1 M HCl and sodium bicarbonate solution, filter, wash the solid with water, dry under vacuum to give 9-methylazathioprine (mp 174-5°). Purify by precipitating from DMF solution with water.) (29)... 

Acetazolaiilde Tablets Azathioprine Tablets Azathioprine Sodiuii for Injection Chlorothiazide Tablets Oichlorphenaaide Tablets Ethacrynate Sodium for Injection Ethacrynic Acid Tablets... 

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