Azaphilone metabolites production

Microbial production of colored azaphilone metabolites (6,7-dihydroisochro-mene-8-one or 6,7-dihydroisoquinoline-7-one derivatives 00CLY105. 

Production of azaphilone metabolites (including also non-halogen compounds) by filamentous fungi is summarized in Table 2. 

Table 2. Production of azaphilone metabolites by filamentous fungi.

The absolute configuration of the Hypoxylon pigments followed X-ray crystallographic analysis of related sclerotiorin (= azaphilone) mould metabolites 714) and comparison of chiroptical data 632). The production of dextrorotatory azaphilones by Hypoxylon is noteworthy since the laevorotatory enantiomers of (272), (273), and (275) have been isolated from Penicillium species 139). 

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