Auxiliary Structures in Pharmaceuticals

Chiral auxiliaries can serve not only as a chiral template, but the structural motif can be incorporated into an active pharmaceutical. Although the chemistry of the chiral writ can be exploited, this is not a true application of an auxiliary as the unit becomes part of the final molecule. 

Oxazoles and isooxazoles are also found in many active drugs although not as prevalent compared with the oxazolidinones, examples include antiinflammatories [37,38] and nitric oxide-associated diseases [39]. 

Although this application area is intriguing, the focus of this chapter remains on the broader application of chiral auxiliaries for asymmetric synthesis. 

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