Autoregulation, cerebral tissue

Studies of Cerebral Tissue Oxygenation and Related Autoregulation... 

Flow to the brain tissue is precisely regulated by a process of autoregulation, according to local chemical conditions. Cerebral blood vessels dilate and so increase blood flow in response to decreased pH and arterial PO2 and to increased arterial PCO2, conditions associated with increased metabolic activity. The neurones are very sensitive to changes in cerebral blood flow interruption of flow for a few seconds causes unconsciousness. 

CT perfusion. Compared to NCCT, dynamic CT perfusion (CTP) has a higher sensitivity for detecting the extent of acute ischemia [78,79]. Evidence indicates that the region of reduced CBV approximates the infarct core [25,73, 80]. One proposed explanation for this finding is that loss of cerebrovascular autoregulation within the infarcted tissue results in the collapse of capillary beds and a decrease in cerebral blood volume [67, 81]. 

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