Autophagy-Dependent Apoptosis in Cancer Therapy

From a small library of 1,4,5-trisubstituted 2,3-triazole compounds 

The biological data suggest that compound 52 inhibits breast cancer cell growth both in vitro and in vivo through induction of autophagy-mediated apoptosis and will help to develop a promising therapeutic strategy for the treatment of breast cancer. 

In addition, chemical stability investigation indicates that the conjugated sugar residue seems to improve the stability of podophyllotoxin residues under the physiological conditions. 

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