Autonomic Drugs The Eye and Cardiovascular System

An acute (painful) or chronic (genetic) condition with increased IOP due to blockade of the canal of Schlemm. Emergency drug management prior to surgery usually involves cholinomimetics, carbonic anhydrase inhibitors, and/or mannitol. 

Carbachol, pilocarpine, echothiophate Cholinomimetic Activation of M receptors causes contraction of ciliary muscle, which increases flow through the canal of Schlemm echothiophate is an organophosphate AChE inhibitor - T outflow 

Apraclonidine epinephrine Sympathomimetic a2 agonist effects (prejunctional) cause 4- NE release — 4. aqueous humor formation E causes T outflow 

Betaxolol, timolol Beta blockers Block actions of NE at ciliary epithelium 4- aqueous humor formation 

Acetazolamide, dorzolamide Carbonic anbydrase inhibitor 4- HCO availability leads to 4- aqueous humor formation 

A chronic condition with increased intraocular pressure (IOP) due to decreased 

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