Automated Synthesis of Poly a- l - 2 -D-Mannosides

Cycle Used with Glycosyl Trichloroacetimidate Activation and Acetate Deprotection 

The facile synthesis of 13 in high yield and purity prompted us to undertake the synthesis of larger poly a- 2) mannosides. Applying the 

Automated Synthesis of /i-Glucans Using Glycosyl Phosphates 

Given our success with the use of trichloroacetmidate donors, we sought to explore the use of glycosyl phosphates in an automated protocol.1 

The phytoalexin elicitor (PE) family of /1-D-glucans (Fig. 5) was selected as a target because these oligosaccharides had been synthesized previously in solution48,49 and on the solid support.50,51 It was our intention to investigate not only the application of glycosyl phosphates to automated solid-phase synthesis, but also to compare our method to the previously described reports of PE syntheses. 

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