Automated synthesis comparative applications

The phytoalexin elicitor (PE) family of /1-D-glucans (Fig. 5) was selected as a target because these oligosaccharides had been synthesized previously in solution48,49 and on the solid support.50,51 It was our intention to investigate not only the application of glycosyl phosphates to automated solid-phase synthesis, but also to compare our method to the previously described reports of PE syntheses. 

Three methodologies are compared the classical solution method, the Merrifield approach and an automated (the "mediatcontinuous monitoring. The utilization of PRs as general acyl transfer reagents is also elaborated. ITie described approaches are not limited to peptide synthesis, but may be applicable to a wide range of organic reaction types. 

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