Autoimmunity clinical assessment

Autoimmunity and hypersensitivity remain significant concerns, but are least amenable to well-controlled preclinical assays and therefore are not well covered in regulatory guidances, and less so in terms of clinical assessment (see Chapters 5.2 and 8). 

Although a number of studies have demonstrated that various metals may play a primary role in mediating PM-related cardiopulmonary health effects and autoimmunity, less is known regarding the potential impacts of environmental exposures to PGE. In particular, very httle data is available regarding the sub-clinical effects of chronic low dose exposures. This is especially relevant regarding attempts to assess the effects of exposures to low concentrations of PGE that are being continuously emitted into the environment. 

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