Autism pathogenesis

Drs. Peter Kirsch and Andreas Meyer-Lindenberg from Mannheim, Germany, are experts on the prosocial neuropeptide oxytocin and discuss its role in humans and its relevance for autism pathogenesis and therapy. In the chapter The Role of the Noradrenergic System in Autism Spectrum Disorders , Dr. David Beversdorf presents the normal role of norepinephrine and its effects on cognition and the possible dysregulation of norepinephrine in autism and possible treatment with propanolol. 

Rett Syndrome A Rosetta Stone for Understanding the Molecular Pathogenesis of Autism Janine M. LaSalle, Amber Hogart, and Karen N. Thatcher... 

Buitelaar JK, WiUemsen-Swinkels SH (2000) Autism current theories regarding its pathogenesis and implications for rational pharmacotherapy. Paediatr Drugs 2 67-81 Campbell JL, Thomas HM, Gabiielli W, Liskow Bl, Powell BJ (1994) Impact of desipramine or carbamazepine on patient retention in outpatient cocaine treatment preliminary findings. J Addict Dis 13 191-199... 

A conference of the American Academy of Pediatrics on new challenges in childhood immunizations was convened in Oak Brook, IL, on 12-13 June 2000 and reviewed data on what is known about the pathogenesis, epidemiology, and genetics of autism and the available data on hypothesized associations with Crohn s disease, measles, and MMR vaccine. The participants concluded that the available evidence did not support the hypothesis that MMR vaccine causes either Crohn s disease or autism or associated disorders. They recommended continued scientific efforts directed to the identification of the causes of autism (69). 

Bernard S, Enayati A, Roger H, Binstock T, Redwood L. The role of mercury in the pathogenesis of autism. Mol Psychiatry 2002 7(Suppl 2) S42-3. 

One interesting concept is the role of oxidative stress in the pathophysiology as well as the association between nicotine and ADHD. Oxidative stress is reported to play an important role in the pathogenesis of many psychiatric disorders. Changes in the oxidant and antioxidant indices have been reported to contribute to autism, developmental disorders, and ADHD [210]. Some... 

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