Authenticity Assessment - Latest Developments

In recent years, enantioselective chromatography was extended to semipreparative separations and now simulated moving-bed technology (SMB) has become available for the resolution of some synthetic racemates in preparative scale. In the pharmaceutical industry this progress is of considerable interest with respect to enantiopure drug applications. 

Presently, online cGC-IRMS determination of 5 C and 5 H values of flavour compounds are established [107. 118-123] and, further on, 5 0 measurements using online cGC-IRMS procedures will be available. Finally, enantio-MDGC combined with multielement- and multicomponent IRMS methods will open the door to comprehensive authenticity assessment of natural flavour and fragrance compounds in the near future. 

So far, general conditions for the official monographs of essential oils are recommended as follows  

Separation on Diluted Methylated jl-Cyclodextrin Derivatives by High Resolution Gas Chromatography. J. High Resolut. Chromatogr.. 12. 383-393 (1989). 

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