Augmented disadvantage

The primary disadvantage is the large volume necessary to replace or augment intravascular volume. Approximately 4 L of normal saline must be infused to replace 1 L of blood loss. In addition, dilution of colloid oncotic pressure leading to pulmonary edema is more likely to follow crystalloid than colloid resuscitation. 

Enhancement in drug delivery and absorption via a specific route of administration often becomes essential in the design of novel pharmaceutical products and new therapies. On the one hand, biotechnological therapeutic molecules usually require enhancers for their successful administration by noninjectable modes alternatively, for the more efficient delivery of conventional drugs, other routes that overcome the disadvantages of traditional administration may also require additional augmentation. 

Glass ampoules have the disadvantage that upon opening glass particles can fall into the solution. To minimize the creation of glass splinters on breaking, ampoules with different break augmenting systems have been developed ... 

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