AuCl PPh

The intramolecular hydroarylation/cyclisation of aryl propargylic acetates catalysed by the system [AuCl(IPr)]/AgBF (1 1, 2 mol%, 72-92%, rt, 5 min) was developed as a versatile and efficient method leading to indene derivatives 110 (Scheme 2.20). Analogous catalytic systems, where the IPr was substituted by PPh, gave lower conversions and chemo-Zregio-selectivity. 

Kozmin has reported the formation of polyqrclic ethers via the gold(I) or gold(III)-catalyzed tandem enyne cydization/alkoxylation of 1,5-enynes that contained a tethered hydroxy group [126]. As an example, treatment of homopropargyUc alcohol 86 with a catalytic 1 1 mixture of (PPhs) AuCl and AgC104 at 20 °C led to isolation of 6-oxabicyclo[3.2.1]octene 87 in 89% yield (Scheme 12.15). Conversion of 86 to 87 presumably occurs via attack of the pendant alkene on a goldhydroxy group at the disubstituted alkenyl carbon atom. Protodeauration then releases heterocycle 87 (Scheme 12.15). 

An 77 -vinylidene interaction is observed in the cluster [Ru3(C0)8 /i2- -C2CPh20C(0) /i3-Au3(PPh)3 ] 70, which is prepared by the sequential attack of K[BHBu 3] and AuCl(PPh3) on the hydrido-alkynyl cluster [Ru3(/i-H)(CO)9 /x-G2GPh2(OH) ]. The reaction proceeds by the intramolecular attack of alkoxide on an adjacent GO ligand. 

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