Attempted Biomimetic Synthesis of 5-Hydroxytiagabine

The hemins were synthesized by the methods of Traylor, Dolphin, and Tsuchiya. Condensation of the appropriate aldehydes (2,6-dichlorobenzaldehyde and pentafluoro-benzaldehyde, respectively) with pyrrole in the the presence of anhydrous zinc chloride in refluxing Intidine yielded the zinc complexes of the porphyrins after chromatographic 

Availability of larger amounts of metabolites would facilitate biochemical, pharmacological, and toxicological studies. Additional details of our work with metalloporphyrins are presented at the end of the chapter. 

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