Atropine drug interactions

Discussion An initial effort to study group behavior when different drugs were present. In a three session double-blind design, each man in rotation received a small dose of BZ, LSD or atropine and the effect on their interactions and performance of simple military tasks was observed, but not scored. It was possible to distinguish which drug each subject had received by clinical examination. This was a pilot study, intended primarily to test the feasibility of using ... 

Thus, the anticholinergic activity of the alkaloid hyoscyamine is almost entirely confined to the (—)-isomer, and the (+)-isomer is almost devoid of activity. The racemic ( )-form, atropine, has approximately half the activity of the laevorotatory enantiomer. An anticholinergic drug blocks the action of the neurotransmitter acetylcholine, and thus occupies the same binding site as acetylcholine. The major interaction with the receptor involves that part of the molecule that mimics acetylcholine, namely the appropriately positioned ester and amine groups. The chiral centre is adjacent to the ester, and also influences binding to the receptor. 

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