Atropine composition

This hydrolysis indicates that the simpler base ecgonine is both an alcohol and an acid and that cocaine is the double ester of this base with benzoic acid and methyl alcohol. Ecgonine bears the same relation to cocaine that tropine does to atropine. In its reaction ecgonine proves to be very similar to tropine and as indicated by its composition formula it differs simply by CO2. 

Achari and Jacob studied several parameters that have an influence on the retention of basic drugs in ion-pair HPLC, i.a. atropine and scopolamine. Some general conclusions were drawn concerning the nature of the pairing-ion, the type of chemically bonded stationary phase and the composition of the mobile phase (Chapter 2). 

Y. Kitamura, H. Miura and M. Sugii, Alkaloid composition and atropine esterase activity in callus and differentiated tissue of Duboisia myoporoides R.Br., Chem. Pharm. Bull., 33 (1985) 5445-5448. 

Recently, the DART technique has been utilized for chemical profiling of hairy root cultures of Atropa acuminata [126], The intact haiiy roots were directly analyzed by holding them in the gap between the DART irm source and the mass spectrometer. Applying a resolving power of6,000, two alkaloids were detected by their elemental composition and characterized as atropine and scopolamine on the basis of exact mass measurements. 

Although the two common solvents, chloroform and carbon tetrachloride, are very closely related in composition, the table of dielectric constants suggests considerable variation in the solvent powers of these two compounds. which prediction is in agreement with actual experience. In many instances, chloroform exhibits an unusual solvent power. This is e.spc(dally noticeable in the solubilities of some of the well-known alkaloids, such a.s atropine, quinine, cinchonine, quinidinc, and hyoscyamine. 

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