Atrial natriuretic peptide substrate

Carboxypeptidase H (EC 3.4.27.10 carboxypeptidase H enkephalin convertase) is not fully characterized, and may be a metalloproteinase. Substrates of this enzyme, found in cell membranes and secretory vesicles, include enkephalins, bradykinin and ATRIAL NATRIURETIC peptide. Two mercapto inhibitors used are MERGETPA (MGTA) and GEMSA, but they are not very selective. 

Carboxypeptidase N (EC 3.4.17.3 kininase I arginase carboxypeptidase) is a zinc-metalloproteinase. Notable substrates of this soluble enzyme include bradykinin (to form [desArg ]-BK, active at B, bradykinin receptors), enkephalins and atrial natriuretic peptide. An inhibitor used is MERGETPA. but it is not very selective. 

Endopeptidase-24.II (EC 3.4.24.11 NELP neutral endopeptidase neprilysin, enkephalinase) is a zinc-metalloproteinase, found both in soluble and plasma membrane forms. It is an important enzyme in neuropeptide degradation. Notable neuropeptide substrates include tachykinins (substance P, neurokinin A, neurokinin B), endothelins (ET-1, ET-2, ET-3), atrial natriuretic peptide, neurotensin, somatostatin and cholecystokinins. 

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