Atherosclerotic neovascularization

Kamat BR, Galli SJ, Barger AC, Lainey LL, Silverman KJ Neovascularization and coronary atherosclerotic plaque cinematographic localization and quantitative histologic analysis. Hum Pathol 1987 18 1036. 

Bobryshev YV, Cherian SM, Inder SJ, Lord RSA (1999) Neovascular expression of VE-cadherin in human atherosclerotic arteries in its relation to intimal inflammation. Cardiovasc Res 43 1003-1017... 

Motexafin lutetium is also in clinical trials, having completed several Phase I and II studies. The completed trials are for the photodynamic treatment of recurrent breast cancer [41,42], light-based treatment of choroidal neovascularization, [43] and the photoangioplastic reduction of atherosclerotic plaque in peripheral [19,44] and coronary arterial disease [20,45], On the basis of these studies, MLu (Antrin Phototherapy) is currently being developed for the treatment of atherosclerotic plaque. Additionally, the National Cancer Institute is testing MLu for the PDT based treatment of prostate [46,47] and cervical cancers. 

Jeziorska M, Woolley DE. Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries. J Rathol 1999 188 189-196. 

In the cardiovascular area, it has been studied for its potential to enhance neovascularization of ischemic tissue, including the myocardium, particularly when delivered locally. By virtue of promoting endothelial cell growth, it is also involved in the recovery of a normal, functional endothelium at the site of vascular injury, for example, after percutaneous coronary intervention. Finally, VEGF appears to have a role in the microvasculature of the atherosclerotic plaque. 

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