Enalapril Atenolol

Sliding scale insulin Allopurinol 1 00 mg orally daily Ranitidine 150 mg orally every 12 hours Atenolol 50 mg orally daily Enalapril 2.5 mg orally daily... 

Q40 A patient with hypertension (male 56 years, weight 55 kg) visits the pharmacy with a new prescription for diclofenac. The patient is already taking enalapril 20 mg daily, atenolol 100 mg daily and... 

Diclofenac is a non-steroidal anti-inflammatory drug. NSAIDs interact with both angiotensin-converting enzyme inhibitors, such as enalapril, and beta-adrenoceptor blockers, such as atenolol, resulting in antagonism to the hypotensive reaction, leading to a hypertensive reaction. NSAIDs interact with... 

Figure 3 Correlation between the fraction absorbed and the membrane permeability in Caco-2 cells. Papp represents the membrane permeability of following 20 compounds, and was obtained by measuring the transcellular transport from the apical-to-basal side in Caco-2 cells. The fraction absorbed was obtained from literature. A amoxicillin, B antipyrine, C atenolol, D caffein, E cephalexin, F cyclosporin A, G enalaprilate, H L-glutamine, I hydrocortisone, J inulin, K D-mannitol, L metoprolol, M L-phenylalanine, N PEG-400, O PEG-4000, P propranolol, Q sucrose, R taurocholate, S terbutaline, T testosterone. Source From Ref. 37.

Figure 6.3 Plot of the fraction of dose absorbed (in %) of various drugs as a function of the permeability estimates in the Caco-2 system. Key 1 D-glucose 2 verapamil 3 piroxicam 4 phenylalanine 5 cyclosporin 6 enalapril 7 cephalexim 8 losartan 9 lisinopril 10 amoxicillin 11 methyldopa 12 naproxen 13 an-tipyrine 14 desipramine 15 propanolol 16 amiloride 17 metoprolol 18 terbu-taline 19 mannitol 20 cimetidine 21 ranitidine 22 enalaprilate 23 atenolol 24 hydrochlorothiazide.

In breastfeeding women, labetalol, atenolol, nifedipine and enalapril are in use either singly or in combination. 

Philipp T, Anlauf M, Distler A, Holzgreve H, Michaelis J, Wellek S. Randomised, double bhnd, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment results of the HANE study. HANE Trial Research Group. BMJ 1997 315(7101) 154-9. 

Helgoland A, Strommen R, Hagelund CH, Tretli S. Enalapril, atenolol, and hydrochlorothiazide in mild to moderate hypertension. A comparative multicentre study in general practice in Norway. Lancet 1986 l(8486) 872-5. 

Webster J, Robb OJ, Witte K, Petrie JC. Single doses of enalapril and atenolol in hypertensive patients treated with bendrofluazide. J Hypertens 1987 5(4) 457-60. 

Noninterfering amiloride, acebutolol, acenocoumarol, acetaminophen, aspirin, allopuri-nol, ambroxol, amoxicillin, atenolol, bendroflumethiazide, benzbromarone, bezafibrate, biperiden, bisacodyl, bromazepam, butizide, captopril, cimetidine, ciprofloxacin, clobu-tinol, clonidine, cotinine, diazepam, diclofenac, digitoxin, digoxin, dihydrocodeine, dihy-droergotamine, diltiazem, doxepin, doxycycline, enalapril, erythromycin, fenoterol, furosemide, glibenclamide, heparin, h3qjoxanthine, ibuprofen, indomethacin, isosorbide... 

The client diagnosed with chronic hypertension is prescribed furosemide (Lasix), a loop diuretic, and enalapril (Vasotec), an ACE inhibitor. The client s blood pressures for the last 3 weeks have averaged 178/95, and the HCP has added atenolol (Tenormin), a beta blocker, to the client s current medication regimen. Which statement is the scientific rationale for including this medication in the client s regimen ... 

Two groups of 26 patients, one with mild to moderate hypertension taking enalapril 20 mg twice daily and the other with severe primary hypertension taking enalapril 20 mg twice daily (with nifedipine 30 mg and atenolol 50 mg daily), were given test doses of aspirin 100 and 300 mg daily for 5 days. The 100-mg dose of aspirin did not alter the efficacy of the antihypertensive drugs, but the 300-mg dose reduced the antihypertensive efficacy in about half the patients in both groups. In these patients, the antihypertensive effects were diminished by 63% in those with mild to moderate hypertension and by 91% in those with severe hypertension. In contrast, another study in 7 patients with hypertension taking enalapril (mean daily dose 12.9 mg) found that aspirin 81 mg or 325 mg daily for... 

In a double-blind, crossover study in hypertensive subjects, the combination of atenolol 50 mg once daily and enalapril 20 mg once daily increased the hypotensive effect of either drug alone, but the effect was 30 to 50% less than additive. ... 

Wii LMH, Chalmers JP, West MJ, Russell AE, Monis MJ, Cain MD, Bune AJC, Soutl te DO. Enalapril and atenolol in essential hypertension attenuation of hypotensive effects in combination. Clin Exp Hypertens( 9ZZ) 10,119-33. 

An isolated report describes a patient who developed severe hyponatraemia 3 days afte bendroflumethiazide 10 mg daily was add to treatment with enalapril 20 mg daily and atenolol 100 mg daily. However, on 2 other occasions she only developed mild hyponatraemia when given bendroflumethiazide alone. An earlier study reported changes in sodium balance due to captopril in all 6 patients with renovascular hypertension and in 11 of 12 patients with essential hypertension sodium loss occurred in 12 of the 18 patients. ... 

In a handful of ca e, patients taking enalapril and/or losartan and other antihypertensive drugs (amlodipine, atenolol, hydrochlorothiazide) had marked increases in blood pressure, hypertensive crises and, in one case, intracranial haemorrhage, within 7 to 60 days of starting orlistat. 

Atenolol and enalapril are drugs used In the treatment of heart disease. Both of these drugs lower blood pressure (albeit in different ways) and reduce the risk of heart attack. Using Table 2.1, identify and label all functional groups in these two compounds ... 

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