Asymmetric Spaces within an Achiral Cylindrical Host

Asymmetric Spaces within an Achiral Cylindrical Host 

Coencapsulation is a process that limits the space provided to trapped guests and obliges them to sense reciprocally simply because they cannot avoid each other. Chirality is a feature related to the spatial distribution of objects, therefore any symmetric closed space becomes chiral if a chiral object is placed in it (Fig. 27A). This simple concept is then applied to spherical and cylindrical capsules in both cases the correct orientation of two chiral guests is necessary to allow interactions between the asymmetric centers of the two partners. In 

27 A A chiral object like a hand in an achiral environment leaves a chiral space available. B Spherical supramolecular capsules are much less suitable compared to C cylindrical ones for enantiorecognition because of the greater number of possible reciprocal orientations of two co-guests encapsulated 

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