Asymmetric organocatalysts chiral guanidines

Over the past decade, rapid growth has been achieved in organocatalytic asymmetric Diels-Alder and hetero-Diels-Alder reactions. Numerous organocatalysts such as chiral amines, guanidines, N-heterocyclic carbenes, Bronsted acids, and bifunctional catalysts have been successfully developed. The activation modes for these catalysts, such as imine-catalysis, enamine-catalysis, dienamine catalysis. 

Reviews have featured recent applications of organocatalysts to asymmetric aldol reactions, including particular focus on catalysis by small molecules. The effects of introduction of a diaryl (oxy)methyl group into chiral auxiliaries, catalysts, and dopants have been discussed and applications of amidine-, isothiourea-, and guanidine-based nucleophilic catalysts for a range of reactions of carbonyl compounds have been highlighted. " ... 

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