Grignard cross-coupling, asymmetric

Carbon-Chiral Allylsilanes by Asymmetric Grignard Cross-Coupling... 

Asymmetric Grignard Cross-Coupling Catalyzed by Chiral... 

More recent review Hayashi, T. Asymmetric Grignard Cross-Coupling Catalyzed by Chiral Phosphine-Nickel and Phosphine-Palladium Complexes, in Asymmetric Reactions and Processes in Chemistry (Eliel, E. L., Otsuka, S. ed.), American Chemical Soc. Symp. Series Vol. 185, p. 177 (1982)... 

In the first reported examples of the asymmetric Grignard cross-coupling, a nickel complex coordinated with (-)-DIOP (1) was used as catalyst [6,7]. Reaction of 1-phenylethyl (2) and 2-butyl (3) Grignard reagents with vinyl chlo-... 

For the first time, a simple and efficient method for the preparation of optically active allylsilanes using catalytic asymmetric Grignard cross-coupling has been reported. These allylsilanes react in a highly efficient and stereocontrolled fashion with aldehydes, in which the reaction is thought to proceed via acyclic linear diastereomeric transition states (Scheme 21). ... 

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