Asymmetric Bis-Alkoxycarbonylation of Alkenes

The former product is derived from P-elimination reaction, whereas the two latter products are obtained by mono-alkoxycarbonylation of the substrate. Some oligomeric species are also often formed. 

Despite these promising results, only a few articles have been reported so far on this asymmetric carbonylation reaction. 

Although much progress has been made over the last years in controlling the regios-electivity of the alkoxycarbonylation reaction, stereoselectivity, which is cmdal in terms of pharmaceutical applications, is stiH to be largely improved. However, because of this industrial interest, a number of patents have alreatfybeen published [74]. 

1 van Leeuwen, P.W.N.M. and Claver, C. (eds) (2000) Rhodium Catalyzed Hydroformylation, Kluwer Academic Press, Dordrecht. 

2 Claver, C., Dieguez, M., Pamies, 0. and Castillon, S., (2006) Topics in Organometallic Chemistry, Catalytic Carbonylation Reactions, Asymmetric Hydroformylation, vol. 18, Springer GmbH, Berlin, p. 35. 

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