Asthma susceptibility genes

Huang SK, Mathias RA, Ehrlich E et al (2003) Evidence for asthma susceptibility genes on chromosome 11 in an African-American population. Hum Genet 113 71-75... 

Novel Asthma Susceptibility Genes Identified through Genome Scans... 

Determine specific target organ disease in atopic individuals Asthma susceptibility genes... 

Xu, J., et al., "Genomewide Screen and Identification of Gene-Gene Interactions for Asthma-Susceptibility Loci in Three U.S. Populations Collaborative Study of the Genetics of Asthma," Am.. Hum. Genet., 68, 1437-1446 (2001). 

Mapp, C. E. et al., Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates, J. Allergy Clin. Immunol., 109, 867, 2002. 

Kere, J., and Laitinen, T. (2004) Positionally cloned susceptibility genes in allergy and asthma. Curr. Opin. Immunol. 16, 689-694. 

Xu, J. F., Meyers, D. A., Ober, C., et al. (2001) Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations collaborative study on the genetics of asthma. Am. J. Hum. Genet. 68, 1437-1446. 

Unfortunately, most diseases of economical and societal interest (e.g., heart disease, cancer, diabetes and asthma) are considered to be such complex diseases, that is, they cannot be attributed to single genes. In this context, the related genes are referred to as susceptibility genes. Such genes may or may not be related functionally they may be unrelated but belong to intrinsic biochemical pathways [8],... 

Mapp, C.E. et al., Association between HLA genes and susceptibility to toluene diisocya-nate-induced asthma, Clin Exp Allergy, 30, 651, 2000. 

Since elucidation of the sequences of the genes encoding the alr a2, and subtypes of adrenoceptors, it has become clear that there are relatively common genetic polymorphisms for many of these receptor subtypes in humans. Some of these may lead to changes in critical amino acid sequences that have pharmacologic importance. Often, distinct polymorphisms occur in specific combination termed haplotypes. Some of these polymorphisms have been consistently shown to alter the susceptibility to diseases such as heart failure, to alter the propensity of a receptor to desensitize, and to alter therapeutic responses to drugs in diseases such as asthma. This remains an area of active research because studies have reported inconsistent results as to the pathophysiologic importance of some polymorphisms. 

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