Asthma pathology

Barrios R et al Asthma Pathology and pathophysiology. Arch Pathol Lab Med 2006 130 447. [PMID 16594736]... 

Melanocortin peptides have been proposed as potent modulators of many pathologies including inflammatory (asthma, arthritis) and cardiovascular disease. They have been shown to be directed against resident cells within tissue such as macrophages, endothelial cells and also circulating leukocytes (neutrophils and lymphocytes). Therefore harnessing their therapeutic potential could lead to the development of novel therapeutics. 

MA Kaliner, PJ Barnes, CGA Persson. Asthma, Its Pathology and Treatment. New York, Marcel Dekker, 1991. 

It is important to remember that respiratory sensitization and asthma are related, but not identical, pathologies [31]. Asthma is a specific syndrome which appears to have genetic as well as environmental causes and there are numerous potential triggers which have been identified by immunotoxicologists [32], However, asthma is not the same disease as other respiratory hypersensitivity syndromes (sometimes referred to as chemical asthma, etc.) [33, 34], Various regulatory guidance documents have sought to deal with the latter disease entities to ensure that xenobiotics are assessed appropriately for their ability to induce immune-based pulmonary hypersensitivity reactions [35-37],... 

Doganci A, Eigenbrod T, Krug N, et al Pathological role of IL-6 in the experimental allergic bronchial asthma in mice. Clin Rev Allergy Immunol 2005 28 257-270. 

The underpressure created in the respiratory tract is the driving force for the airflow through an inhalation device. The attainable underpressure and the rate of the airflow both depend on the total resistance in the airways and inhaler. The pressure drop achieved during inhalation is furthermore a function of the anatomy of the lungs, the effort made by the patient, pathological factors and the presence of exacerbations (e.g. in case of asthma). 

Bronchial biopsies of subjects with occupational asthma induced by TDI revealed pathologic features such as increased number of inflammatory cells in the airway mucosa and thickening of subepithelial collagen. ... 

Mainly because the molecular mechanism of these pathological changes has not been sufficiently studied, therapy of asthma, pulmonary illnesses, and other respiratory system illnesses are generally aimed at preventing and relieving symptoms that accompany the disease. 

V.V. Nikonov et al, proposed use of massive doses of Enterosgel combined with Eortrans laxative and various eubiotics as the means for prophylaxis of endotox-emia, oxidative stress and bacterial translocation during preparation for surgery associated with the risk of massive blood loss, and in critical state patients with multi-organ insufficiency, severe bums, sepsis, and polytrauma [56]. This scheme may be used for therapy of different pathologies such as chronic hepatitis, allergy and exacerbation of bronchial asthma. 

Although there are only four herbs in the formula, they fit the pathological change of the syndrome perfectly. In clinical practice, this formula is very effective for treating acute bronchitis, pneumonia and asthma. 

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