Astatine biomedical applications

Astatine can be readily and routinely obtained in an inorganic form suitable for chemical and biomedical application from the a-irradiated bismuth target by either extractive (7, 113, 116) or dry 2, 3, 48, 74, 93, 120) distillation techniques. Both methods have their relative merits (55.101). 

Astatine, 6 207-223, 31 43-88 as astatate ion, 6 219-220 as astatide ion, properties of, 6 217-218 biochemical compounds of, 6 222 biochemical fate, 31 78 biological behavior, 6 222 31 77-78 biomedical applications, 31 79-83 therapeutic studies, 31 80-81 chemical properties of, 6 216 diatomic, 31 50 distallation, 31 47-48 elementary, 6 218-219 embryotoxicity, 31 78 extraction techniques, 31 47 identification, 31 49 in intermediate oxidation state, 6 219 iodide, 6 218-219 isotopes, 31 43-49 decay, 31 44 half-lives, 31 44 decay and half-lives of, 6 210 experimental methods for, 6 213-216 production and measurement of, 6 209-216... 

A separate section is devoted to the biomedical applications of 211At-labelled species because of their increased role in astatine research. 

The properties of organic astatine compounds applicable for biomedical studies have been investigated with special emphasis on the stability of the C—At bond under changing temperature and pH conditions, in the presence of oxidizing or reducing agents as well as—in some cases—in vivo. 

Astatine Its Organonuclear Chemistry and Biomedical Applications J. Brown... 

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