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Assessing Drug-Likeness

Collect drug- lead-like screening compounds from renowned vendors and assess drug-likeness... [Pg.50]

Vistoli, G., Pedretti, A. and Testa, B. (2008) Assessing drug-likeness what are we missing Drug Discovery Today, 13, 285-294. [Pg.99]

Another simple appHcation of the PSA is in assessing drug-like properties of molecules. Today, PSA is commonly used as an extension of the rule of 5. A high PSA indicates an increased risk of bioavailability problems for a compound. However, the predictivity of a PSA model must not be overstressed. The physico-chemical properties of a compound only influence its behavior in passive diffusion through a membrane. Other effects, such as active transport, are not considered at all. [Pg.583]

See other pages where Assessing Drug-Likeness is mentioned: [Pg.245]    [Pg.245]    [Pg.245]    [Pg.245]    [Pg.247]    [Pg.249]    [Pg.527]    [Pg.87]    [Pg.111]    [Pg.146]    [Pg.147]    [Pg.148]    [Pg.148]    [Pg.245]    [Pg.245]    [Pg.245]    [Pg.245]    [Pg.247]    [Pg.249]    [Pg.527]   


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