Assays involving more specialised HPLC techniques

Assays involving more specialised HPLC techniques [Pg.264]

Although more than 80% of all separations by HPLC utilise reverse-phase chromatography, there are certain analytes which require more specialised chromatographic methods. A few examples are given in the following section. [Pg.264]

Assay of adrenaline injection by chromatography with an anionic ion-pairing agent [Pg.264]

Injections of local anaesthetics often contain low concentrations of adrenaline in order to localise the anaesthetic for a time by constricting blood vessels in the vicinity of the injection. Adrenaline can be analysed by straight-phase chromatography, for instance on silica gel, but this generally requires strongly basic conditions under which the catechol group in adrenaline is unstable. Adrenaline is [Pg.264]

Interaction of adrenaline with an ion-pairing agent coated onto an ODS stationary phase. [Pg.265]

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