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Assays in Endocrine Safety Pharmacology

This section describes the measurement of pituitary hormones in the context of repeated dose studies of 1-4 weeks duration. When performing an endocrine safety pharmacology study in rats it is advisable to determine pituitary hormone concentrations at autopsy, because in this species specific pituitary hormone assays are readily available. The time point two hours after last dosing is in general suitable, when changes in pituitary hormone contents need to be assessed. [Pg.336]

See other pages where Assays in Endocrine Safety Pharmacology is mentioned: [Pg.327]    [Pg.328]    [Pg.330]    [Pg.332]    [Pg.334]    [Pg.336]    [Pg.338]    [Pg.340]    [Pg.342]    [Pg.344]    [Pg.346]    [Pg.348]    [Pg.350]    [Pg.352]    [Pg.354]    [Pg.356]    [Pg.358]    [Pg.360]    [Pg.362]    [Pg.327]    [Pg.328]    [Pg.330]    [Pg.332]    [Pg.334]    [Pg.336]    [Pg.338]    [Pg.340]    [Pg.342]    [Pg.344]    [Pg.346]    [Pg.348]    [Pg.350]    [Pg.352]    [Pg.354]    [Pg.356]    [Pg.358]    [Pg.360]    [Pg.362]    [Pg.328]   


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