Assays for Testing the Induction of Autoimmunity

Because of the idiosyncratic nature of chemical induced autoimmunity (including drug allergy) it is impossible to predict this phenomenon in routine toxicity studies 

Some studies have demonstrated that chemicals can increase autoimmune disease in autoimmune-prone mice (e.g, NZB mice) [70, 81, 82]. Together, these and other examples demonstrate that indeed chemical-induced autoimmunity can be induced in ariimals. However, these examples also show that a chemical may require very specific circumstances to induce autoimmune phenomena. In other words, it may be an illusion that one single animal model will be found or developed that will cover all different chemical-related autoimmune diseases. 

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