Fragment screening assay techniques

This research has progressed only because the science was willing to allow Nature s biomolecules to intervene earlier than is usual for medicinal chemistry protocols. The role of biomolecules has been elevated from spectator to key player, to guide and instruct the synthesis of potent inhibitor molecules, while the medicinal chemist acts to facilitate this process. The in situ selection and assembly of fragments could in principle be screened by an activity assay or by any number of analytical techniques for drug discovery, however, it is a... 

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