Aspirin cholestyramine binding

The answer is c. (Hardman, pp 887, 889.) Bile acid-binding resins bind more than just bile acids, and binding of simvastatin to cholestyramine is the most likely mechanism for decreased Gl absorption. Cholestyramine may also bind to several other drugs, including digoxin, benzothiadiazides (thiazides), warfarin, vancomycin, thyroxine (T4), and aspirin. Medications should be given one hour before or four hours after cholestyramine. 

Cholestyramine resin does not bind with drags that xt neutral or with amine salts acidic drugs (in the anion fonv-could be bound, however. For example, in animal tests, ak sorption of aspirin given concurrently with the resin Hi-depressed only moderately during the first. 30 minutes. 

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