Aspirin angina pectoris

Coronary artery disease Due to the vasodilatory effect of dipyridamole, use with caution in patients with severe coronary artery disease (eg, unstable angina, recently sustained Ml). Chest pain may be aggravated in patients with underlying coronary artery disease who are receiving dipyridamole. For stroke or transient ischemic attack patients for whom aspirin is indicated to prevent recurrent Ml or angina pectoris, the aspirin in this product may not provide adequate treatment for the cardiac indications. 

Herbs have been used as medical treatments since the beginning of civilization and some herbal derivatives (e.g., aspirin, reserpine, and digitalis) have become a mainstay of human pharmacotherapy. For cardiovascular diseases, herbal treatments have been used in patients with congestive heart failure, systolic hypertension, angina pectoris, atherosclerosis, cerebral insufficiency, venous insufficiency, and arrhythmia. Scientific validation of several plant species has proved the efficacy of the botanicals in reducing the... 

Pectoris Aspirin Trial (SAPAT) Group. Double-blind trial of aspirin in juimary prevention of myocardial infarction in patients with stable chronic angina pectoris. Lancet 1992 340 1421-1425. 

Apart from rare reports of variant angina pectoris and vasculitis theoretically related to thromboxane, aspirin is not associated with adverse effects on the cardiovascular system (17,18), except an increase in circulating plasma volume after large doses. 

Task forces from the ACC and the AHA have published guidelines that are useful in the selection of appropriate initial therapy for patients with chronic stable angina pectoris (www.americanheart.org). Patients with coronary artery disease should be treated with aspirin and a P adrenergic receptor antagonist (particularly if there is a history of prior MI). The guidelines also... 

Death In a registry-based study of 58 465 Swedish patients with diabetes aspirin significantly increased the risk of death in those without cardiovascular disease (previous or acute myocardial infarction, angina pectoris, ischemic stroke, transient ischemic attack, intermittent claudication, previous coronary artery bypass graft surgery, or percutaneous coronary intervention) by 17% (95% Cl = 1, 36) at age 50 years and by 29% (95% Cl = 16, 43) at age 85 years [70 ]. In elderly patients with diabetes with cardiovascular disease who used aspirin there was a non-significant trend towards reduced mortality, by 11% at age 85 years. The risk of serious bleeding was also increased by aspirin in those without cardiovascular disease and reduced by aspirin in those with cardiovascular disease. 

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