Asparagine metal complexes

Asparagine prebiotic systems, 871 Aspartate transcarbamylase zinc, 606 Aspartic acid metal complexes, 858 prebiotic systems, 871 Aspartic acid, p-carboxy-synthesis... 

These polymers consist of a synthetic polymer backbone onto which amino acids or peptides are grafted as side chains. Examples of materials with amino acids as side chains have been found to exhibit polyelectrolytic and metal complexation behaviour. Such systems include polymethacrylamides with glycylglycine and phenylalanine (Methenitis, 1994), as well as alanine, aspartic acid, asparagine, glutamic acid, and lysine (Morcellet-Sauvage, 1981 Morcellet, 1982 Lekchiri, 1987). 

A study of the mixed complexes formed by metal interactions with asparagine and glutamine has shown that quite a large proportion of asparagine in blood may be co-ordinated to zinc(n) and iron(n) as well as copper(n).246... 

Histidine and asparagine function as tridentate chelates. In the asparagine complexes, the mixed (dl) form is the more stable while the reverse is true of the histidine complexes. Potentiometric studies of the complexes of various metals (Nill, Cull, Coll, Znll) with a wide range of amino adds all of which function as bidentate chelates have failed to reveal any differences in the stability of Mdl and Mll forms. (Ritsma et al. 1965 Gillard et al. 1966). The reason why the chirodiastaltic interactions should be so much more marked with tridentate than bidentate chelates calls for investigation in terms of the intramolecular force system. 

I.r. and X-ray-induced photoelectron spectra of the complexes [M4(OH)g-(NH3CH2C02)8]Xg,12H20 (M = Zr or Hf X = Cl, Br, or NO3) have shown that the glycine molecules are O-bonded to the metal atoms. " A similar conclusion has been deduced from i.r. spectral studies of the Zr40(0H)g-(NH3CH2C02) ,(14 — n)H20 (n = 4—12) complexes. Stepwise stability constants have been reported for the complexes of zirconium(iv) with diphenyl-amine-2,2 -dicarboxylic acid, asparagine, and gjutamine. ... 

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