Asian phenotypes function

Second, there are often different variants in different populations some phenotypic consequences of CYP2D6 variations are shown as an example in Figure 2 (1). There is a lower average enzyme activity in both, Chinese and Africans, in comparison to that in Europeans. These differences in activity represent structural changes of the CYP2D6 protein that affect enzyme function. However, the enzyme structures that cause the lower activities are different in the Chinese (13) and in the African populations (14). It is an independent fact that enzyme absence is more rare in Asians and Africans than in Europeans (4). 

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