5-Arylthio-1,2,4-triazines

The cyclization of 5-hydrazine-6-arylthio[l,2,4[triazin-3(2//)-ones 849 was effected by formic acid to give 950 (74MIP1). They are potentially useful as antibacterial, antiviral, and antimetabolic agents. Cyclization of... 

Very little is known about the susceptibility of the ring nitrogen atoms in 1,2,3-triazine derivatives to N-oxidation. Attempts to oxidize the N-aryl- 77 and iV-alkyltriazinium (79) betaines to the corresponding 1-oxides under a variety of conditions were unsuccessful, and the betaines were recovered unchanged even after prolonged exposure to powerful oxidants.It has been reported that oxidation of the 4-arylthio-1,2,3-benzotriazine (109) takes place at nitrogen rather than sulfur, and the product has been formulated as the Nj-oxide (110) or the N,-isomer. The evidence in favor of structure 110— the lack of bands... 

Acenaphtho[ 1,2-e][ 1,2,4]triazines synthesis, 3, 434 Acenaphthylene episulfide synthesis, 7, 181 Acenocoumarol application, 3, 881 Acetaldehyde ethylhydrazone NMR, 2, 117 Acetaldehyde, arylthio-dialkyl acetals... 

Patent Aryloxy- and Arylthio-substituted Pyrimidines and Triazines and... 

A 2-methylthio group on 4-pyrimidinones and on 6-amino-4-pyrimidinones (135) is displaced by methylamine acetate and by various salts of ammonia and other amines. Similarly, substitution by hydroxy groups occurs in hot aqueous acid with 2-arylthio- or -alkylthio-pyrimidines. Methylthio appears to be a better leaving group than a methoxy group on pyrimidine but not on -triazine. A 2-methylthio group on pyrimidine is stable to many nucleophiles (NH3, OCHs, CHsNH2) but can be displaced by... 

The dienophilic group can also be linked to the triazine system through an aryl <8775159, 89JOC1245), an aryloxy <8775159,90H(30)1009> or arylthio group <89CB2177>, or an aryl ester function <90H(30)1009> (169), (170). 

Heating 4-amino-3-arylthio-l,2,4-triazin-5(4//)-ones (241) in toluene afforded the tricyclic compounds (242) (Equation (27)) <87S1134>. 

Treatment of 1,2,4-triazine 4-oxides 26, activated by TFA, with thiophenol or its derivatives affords 5-arylthio-... 

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