Antimetabolic Agents

The cyclization of 5-hydrazine-6-arylthio[l,2,4[triazin-3(2//)-ones 849 was effected by formic acid to give 950 (74MIP1). They are potentially useful as antibacterial, antiviral, and antimetabolic agents. Cyclization of... 

Anticancer antimetabolites Antimetabolic agents An-tineoplastic antimetabolites... 

Idoxuridine (9.7) and trifluridine (9.8) are antiviral agents that are phosphorylated to their active form in virus-infected cells, and thus show specificity for two reasons their higher affinity for the viral enzyme, and the higher phosphorylase levels in viral-infected than in normal cells. Both compounds have been used locally on lesions of HSV-1 and HSV-2 (the latter of which causes genital herpes, now reaching epidemic proportions) with fair success. They are rather toxic if administered parenterally, as are all moderately selective antimetabolities. 

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