2-Arylpropionic acids stationary phase

Alcaro, S. et al., Enantioselective semi-preparative HPLC of two 2-arylpropionic acids on glycopeptides containing chiral stationary phases, Tetrahedron Asymmetry, 13, 69, 2002. 

Okamoto, Y., Aburatani, R., Kaida, Y., Hatada, K., Inotsume, N., and Nakano, M. (1989) Direct chromatographic separation of 2-arylpropionic acid enantiomers using tris(3,5-dimethylphenylcarbamate)s of cellulose and amylose as chiral stationary phases, Chirality 1, 239-242. 

The enantiomeric purity of 2-arylpropionic acids used as pharmaceuticals was determined after derivatizing to the corresponding amides with various PAA and HAA. End analysis was by HPLC-UVD, with simultaneous measurement at 230 and 254 nm, using a cellulose-based stationary phase. The best derivative for routine determinations was chosen in each case after establishing the chromatographic parameters of the enantiomeric pair of derivatives197. 

Calleri, E., Massolini, G., Loiodice, F., Fracchiolla, G.,Temporini, C., Felix, G., Tortorella, P., Caccialanza, G. Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids,/. Chromatogr. A, 2002,958, 131-140. 

Van Overbeke, A. Baeyens, W. Van den Bossche, W. Dewaele, C. Separation of 2-arylpropionic acids on a cellulose based chiral stationary phase by RP-HPLC. J.Pharm.BiomedAnal., 1994, 12, 901-909... 

Figure 7 Chiral HPLC separation of 2-arylpropionic acid derivatives on nonimprinted (a) and (5)-naproxen-imprinted stationary phase (b). (1) Racemic ketoprofen, (2) racemic ibu-profen, (3) (R)-naproxen, (4) (5)-naproxen. Mobile phase, 20 mM phosphate buffer pH 3.2 -acetonitrile 1 + lv/v. Columns 100 x 4.6 mm. Flow rate, ImL/min. Detection, UV 254 nm. Reproduced from Ref. 45, with permission.

Aboul-Enein, H.Y. El-Awady, M.I. Heard, C.H. Enantiomeric resolution of some 2-arylpropionic acids using L-(-)serine impregnated silica as stationary phase by thin layer chromatography. J. Pharm. Biomed. Anal. 2003, 32,1055-1059. 

Aboul-Enien, H.Y., El-Awady, M.I., and Heard, C.M., Thin layer chromatographic resolution of some 2-arylpropionic acid enantiomers using L-(—)-serine, L-(—)-threonine and a mixture of L-(—)-serine, L-(-)-threonine-impregnated sihca gel as stationary phases, Biomed. Chromatogr., 17, 325, 2003. 

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