3-aryloxy-5-amino

Schem 2-5. Asymmetric reduction of aryloxy amino ketones.

The R group can be an alkoxy, aryloxy, amino, alkyl, heterocyclic ring or an inorganic or organometallic unit. Allcock and co-workers were the first who did study extensively the synthesis of poly[(organo)phosphazene] derivatives. Most polyphosphazene derivatives are prepared starting from a precursor polymer, poly[(dichloro)phosphazene]. A variety of polymers with variable properties can be prepared by nucleophilic displacement reactions (Allcock, 1972, 1979, 1986) (Figure 2). 

Oxidation of aryloxy amino alcohols 1854 with activated DMSO provided a convenient one-pot method for synthesizing hydroxyimines 1856 without isolation of the unstable intermediate ketones 1855 [1387]. Assignment of the (Z)- and ( )-... 

Benzothiazole, 2-amino-6-thiocyanato-azo dyes from, 1, 328 Benzothiazole, 2-aryl-synthesis, 6, 321 Benzothiazole, 2-arylamino-synthesis, 6, 323 Benzothiazole, 2-aryloxy-Fries rearrangement, 6, 289 Benzothiazole, 2-benzyl-picrate, 6, 252 Benzothiazole, 2-chloro-dyes from, 1, 321-322 synthesis, 6, 323 Benzothiazole, 2,3-dihydro-oxidation, 6, 272 Benzothiazole, 2-dimethylamino-synthesis, 5, 128... 

These are arranged alphabetically according to the atom attached to the ring carbon, halogen, nitrogen (amino, nitro, etc.), oxygen (alkoxy, aryloxy, hydroxy, phosphoryloxy, sulfonyloxy, etc.), and... 

Reaction of 9-bromo-2-morphohno-4//-pyrido[l, 2-n]pyrimidin-4-ones with 4-vinylpyridine in DMF at 80 °C for 16 h in the presence of CS2CO3 and PdCbCdppf), and with amines and phenols in boiling THF for 20 h in the presence of KOr-Bu and PdCbCdppf) yielded 9-[2-(4-pyridyl)vinyl), 9-(substituted amino), and 9-aryloxy derivatives, respectively (01MIP9). 4-Hydroxyaniline gave a 9-(4-hydroxyphenyl)amino derivative. 

In basischer Pufferlosung lassen sich bei -1 V aus Nitro-alkoxy(aryloxy)-benzolcn se-lektiv die Hydroxylamine herstellen in schwach saurem Milieu (Acetatpuffer, bei -1,6 V) erhalt man Amine. In starker saurem Milieu entstehen aus den 4-AIkoxy-Derivaten unter Atherspaltung Amino-phenole6 ... 

Amino-aryloxy- 684 4-Amino-l-cyclohcxyl- 685 4-Amino-l -dichloracetamino- 782... 

As already reported in Table 6, the solubility of phosphazene polymers is strongly influenced by the nature of the substituent groups attached at the phosphorus atoms along the -P=N- skeleton. Water-solubility, for instance, can be induced in polyphosphazenes by using strongly polar substituents (e.g. methylamine [84], glucosyl [495], glyceryl [496], polyoxyethylene mono-methylether [273] or sulfonic acid [497,498] derivatives), or may be promoted by acids or bases when basic (amino substituents like ethylamine [499]) or acid (e.g. aryloxy carboxylate [499] or aryloxy hydroxylate [295]) substituents are exploited. 

Excellent asymmetric hydrogenation of amino ketones has been applied for the syntheses of many chiral drugs. For example, the enantioselective hydrogenation of 3-aryloxy-2-oxo-l-propylamine derivatives can directly afford the l-amino-3-aryloxy-2-propanol derivatives as chiral / -adrenergic blocking agents. This has been successfully accomplished with a neutral MCCPM-Rh complex as the catalyst. With 0.01 mol.% of an (A,A)-MCCPM-Rh complex,... 

Compounds which are of interest in this context include 4-oxadiazolylpyrid-azines (35, R = cyclopropyl, Et) [117], 6-aryloxy-2-hydroxyalkyI-3(27/)-pyri-dazinones [118], 3-halo-6-hydrazinopyridazines of type (36, R = substituted amino) [119], Ar-2-isoxazolylmethyl-substituted 3-iminopyridazines (37) [ 120], carbamates derived from 3,6-bis(hydroxymethyl)-4-pyridazinones (38, R = alkyl, Ph) [121], and iminodihydropyridazine derivatives (39, R1 = acyl R2 = H,MeS R3 = aryl) [122, 123]. In Hungary, antidepressant activity has been observed with some 3,6-disubstituted pyridazines of type (40) [124]. 

Aryl-, aryloxy- and arylthiocarboxylic acids, N-derivatized amino acids Quinine and quinidine carbamates Methanol—0.1 M 194 ammonium acetate, pH 6.0 (80 20)... 

Many triazole derivatives are accessible by exchange of 3- or 5- halo, hydroxy, alkoxy, aryloxy, alkylthio, amino, or cyano groups <67EGP59288, 69BRP1157256, 70KGS1701,75BSF1649). A kinetic comparison of haloazole reactivities has been reported <67JCS(B)64l). 

Amino-l,2,3,4-thiatriazole (207) when acylated with 0-aryl chlorothioformate (208) transforms into an unstable 5-aryloxy-3-imino-l,2,4-dithiazole hydrochloride (209). Acylation of this compound produces 2,5-bis(aryloxy)-l,6,6aA -trithia-3,4-diazapentalene ([210), which may be obtained more conveniently by acylating (207) with two equivalents of (208) (Scheme 44) <89M( 120)997, 90JPR208>. 

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