Arylacetic Acids and Esters

Arylacetic Acids and Esters. - The anti-inflammatory properties of these compounds continues to stimulate new work in this area existing approaches have been summarisd in a review. 3 Another version of the well established [1.2]-aryl migration route to phenylacetic acids consists simply of treatment of the 

An alternative route to phenylacetic acids from acetophenones 

Benzylic Grignard reagents, derived from the corresponding styrenes by nickel- or titanium-catalysed hydromagnesation, can be carboxylated to provide an alternative anion-based approach to phenylacetic acids. 1 

Finally, it is worth noting that Friedel-Crafts acylations of 

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