Aryl-sulphatase

Careful examination of the yellowish sediment obtained after spinning down the crude mitochondrial fraction showed it was frequently overlaid with loosely packed, fluffy material —the fluffy layer. Experiments from de Duve s and, later, Novikoff s laboratories in the 1950s demonstrated that the lighter, lysosomal fraction was enriched in a number of hydrolases including acid phosphatase, aryl sulphatase, B glucuronidase, RNAase, and a peptidase, cathepsin. All the enzymes had optimal pHs in the acid range (pH 5-pH 6). Density... 

Kang, H. and Freeman, C. (1999) Phosphatase and aryl-sulphatase activities in wetland soils annual variation and controlling factors. Soil Biology and Biochemistry31,449-454. 

A variant form shows a far wider range of stored products, including glycosaminoglycans and cholesteryl sulphate. In this there is deficit of aryl sulphatases A, B and C. Thus, this is a disease that is a mucopolysaccharidosis of the Maroteaux-Lamy type, superimposed upon classical metachromatic leukodystrophy, with a lack of aryl sulphatase C leading to a further accumulation of a steroidal sulphate. 

Cytochrome P450 Alcohol dehydrogenase Aldehyde dehydrogenase Aldehyde oxidase Carboxylesterase Aiylesterase Acetylesterase Aryl 4-hydroxylase Aryl sulphatase... 

Balasubramanian, A. S., and B.K. Bachhawat Purification and properties of an aryl-sulphatase from human brain. J. Neurochem. 10, 201 (1963). 

Attempts to retard the synthesis of sulphatides by elimination of Vitamin A from the diet, or by intravenous 2md intrathecal administration of aryl-sulphatase A [79], did not succeed [76, 80]. 

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