Aryl hydrocarbon hydroxylase hepatic microsomal

Table III. Inhibition of monooxygenase (aryl hydrocarbon hydroxylase) activity in fish and mammalian hepatic microsomes (based on...

Bend, J. R., Hall, P., and Foureman, G. L. Comparison of benzo(a)pyrene hydroxylase (aryl hydrocarbon hydroxylase, AHH) activities in hepatic microsomes from untreated and 1,2,3,4-dibenzanthracene (DBA)-induced little skate (Raja erinacea). Bull. Mt. Desert Island Biol. Lab. (1976) 16. 3-5. 

Table IV. Aryl Hydrocarbon Hydroxylase Activity in Hepatic Microsomes from Animals Consuming Various Levels and Types of Fat 0.3% BHT...

Rats were dosed with soil suspensions, by gavage, either once or for four consecutive days. Total TCDD dosages administered to rats were either 10 ug TCDD/kg or 40 ug/ TCDD/kg. Rats were sacrificed 24 hours after the final dose, autopsied, and hepatic microsomal fractions were collected. Aryl hydrocarbon hydroxylase (AHH) levels were determined in the microsomes, using the fluorescent assay of the product of the metabolism of benzo(a)pyrene to 3-OH benzo(a)pyrene (16). 

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